Publications by authors named "L Hirt"
Ischemic stroke is the result of a permanent or transient occlusion of a brain artery, leading to irreversible tissue injury and long-term sequelae. Despite ongoing advancements in revascularization techniques, stroke remains the second leading cause of death worldwide. A comprehensive understanding of the complex and interconnected mechanisms, along with the endogenous mediators that modulate stroke responses is essential for the development of effective interventions.
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- Recent trends show a preference for the endoscopic endonasal transcavernous approach (EETA) over the pretemporal transcavernous approach (PTA) for treating cavernous sinus pathologies, but more evaluation of surgical exposure is needed.
- A morphometric study on latex-injected specimens compared the exposure volumes of EETA, PTA, and a combined EETA-PTA approach, with the latter showing the best results.
- The EETA-PTA combined approach provided the largest surgical exposure volume while avoiding the need to manipulate critical structures like the internal carotid artery, suggesting its effectiveness for complex lesions in the cavernous sinus.
Caveolins are a family of transmembrane proteins located in caveolae, small lipid raft invaginations of the plasma membrane. The roles of caveolin-enriched lipid rafts are diverse, and include mechano-protection, lipid homeostasis, metabolism, transport, and cell signaling. Caveolin-1 (Cav-1) and other caveolins were described in endothelial cells and later in other cell types of the central nervous system (CNS), including neurons, astrocytes, oligodendrocytes, microglia, and pericytes.
View Article and Find Full Text PDFBackground: For high-risk patients receiving right-sided colectomy, stoma formation is a safety strategy. Options are anastomosis with loop ileostomy, end ileostomy, or split stoma. The aim is to compare the outcome of these three options.
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- The study investigates whether deep brain stimulation (DBS) for Parkinson's disease can improve sleep quality, particularly in the early stages of treatment.
- Polysomnography was conducted over three nights with 14 patients, and sleep patterns were analyzed to see if immediate improvements occurred with the start of DBS.
- Results showed significant sleep disruptions persisted despite stimulation, suggesting one night of treatment is not enough to affect sleep architecture in these patients.