Publications by authors named "L Hincapie"
Background: Variants in and (encoding apolipoprotein E and presenilin 1, respectively) alter the risk of Alzheimer's disease. We previously reported a delay of cognitive impairment in a person with autosomal dominant Alzheimer's disease caused by the variant who also had two copies of the apolipoprotein E3 Christchurch variant ( ). Heterozygosity for the variant may influence the age at which the onset of cognitive impairment occurs.
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- The Colombian population shows a unique genetic background due to a mix of Native American, Spanish, and African ancestries, influenced by past population bottlenecks caused by diseases.
- Through genetic analysis of 900 individuals, including those with Alzheimer's and other neurodegenerative disorders, researchers identified how historical admixture has shaped the occurrence of disease-related mutations.
- The study found 21 pathogenic variants related to neurodegenerative diseases, with significant variation in risk based on ancestry, highlighting the importance of demographic history in understanding genetic diseases in the Colombian population.
Introduction: Congenital heart diseases are the most common congenital abnormalities in newborns with a prevalence of 1%. Therapeutic and diagnostic cardiac catheterization has revolutionized the treatment of these diseases; however, it can be associated with complications.
Objective: To describe the incidence and type of complications associated with pediatric cardiac catheterization in a reference center for congenital heart defects.
Objective: To evaluate whether the implementation of care bundles has an impact on resource utilization in the care of patients with postpartum hemorrhage (PPH).
Methods: Retrospective, cross-sectional, observational study of 404 patients with stage II or greater PPH. Periods 2011-2014 and 2015-2017, before and after the introduction of care bundles, were compared.
The diagnosis of ovarian tumors in dogs is usually complicated because the clinical signs can be very discrete and can be easily confused with other diseases. There are few reports of ovarian tumors with different cellular characteristics in the same dog. Our objective was to describe an unusual case of the concomitant presence of ovarian teratoma and granulosa cell tumors in a female dog presenting symptoms compatible with pyometra at clinical consultation.
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