Publications by authors named "L Heuer"
Background: Cognitive impairment is common in neurologic diseases. Precise measurement of cognitive change over time is necessary for isolating disease-related patterns from normal age-related decline. Existing measures of subjective cognition, however, focus on present status.
View Article and Find Full Text PDFAutoimmune diseases (ADs) showcase the intricate balance between the immune system's protective functions and its potential for self-inflicted damage. These disorders arise from the immune system's erroneous targeting of the body's tissues, resulting in damage and disease. The ability of T cells to distinguish between self and non-self-antigens is pivotal to averting autoimmune reactions.
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- There is growing interest in using dietary changes, specifically a diet rich in propionate, to influence autoimmune diseases due to its connection with gut health.
- The study focused on the effects of feeding propionylated high-amylose resistant starches (HAMSP) to mice with primary biliary cholangitis, assessing immune response and liver health through various biological analyses.
- The findings reveal that long-term HAMSP intake shifted T-cell populations and caused liver fat accumulation (hepatocellular steatosis), highlighting the complex relationship between diet and autoimmune conditions.
Classical metabolomic and new metabolic network methods were used to study the developmental features of autism spectrum disorder (ASD) in newborns (n = 205) and 5-year-old children (n = 53). Eighty percent of the metabolic impact in ASD was caused by 14 shared biochemical pathways that led to decreased anti-inflammatory and antioxidant defenses, and to increased physiologic stress molecules like lactate, glycerol, cholesterol, and ceramides. CIRCOS plots and a new metabolic network parameter, , revealed differences in both the kind and degree of network connectivity.
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- - Dirofilaria immitis is a parasitic worm that causes heartworm disease mainly in dogs, and there's rising concern about its resistance to standard preventative treatments known as macrocyclic lactones (MLs) in the USA.
- - Recent studies show that some D. immitis strains in the USA have distinct genetic traits that help identify their resistance to MLs, including specific genetic markers (SNPs) useful for tracking the spread of this resistance.
- - Research involving laboratory-maintained and European clinical samples indicates that while there is resistance in the USA, many genotypes in Europe still respond well to ML treatments, highlighting the need for effective monitoring and compliance with prevention strategies.