Publications by authors named "L Herlitz"
Article Synopsis
- C3 glomerulopathy is a rare autoimmune kidney disease linked to abnormal activation of the alternate complement pathway, leading to potential kidney failure.
- A study tested the drug avacopan in 57 patients, measuring its safety and efficacy over a median of 60 weeks, but results showed no significant improvement compared to a placebo group in key kidney function metrics.
- The primary goal of the study wasn't achieved, indicating that while avacopan's effects on kidney function were inconsistent, further research is needed to explore its potential benefits.
Background: Monitoring the incidence of chronic health conditions (CHCs) in childhood in England, using administrative data to derive numerators and denominators, is challenged by unmeasured migration. We used open and closed birth cohort designs to estimate the cumulative incidence of CHCs to age 16 years.
Methods: In closed cohorts, we identified all births in Hospital Episode Statistics (HES) from 2002/3 to 2011/12, followed to 2018/19 (maximum age 8 to 16 years), censoring on death, first non-England residence record or 16th birthday.
Article Synopsis
- The study investigates diabetic kidney disease (DKD) and its differentiation from non-diabetic kidney disease (non-DKD), which is significant because accurate diagnosis is crucial for patient treatment outcomes.
- It analyzes data from 1,242 diabetic patients at the Cleveland Clinic, revealing that 62.8% had non-DKD with varying alternative kidney diagnoses, while links to some health factors such as retinopathy and A1c levels were identified.
- The study uses a multivariate logistic regression model to attribute specific characteristics—like lower A1c levels and no retinopathy—to a higher likelihood of having non-DKD, suggesting potential diagnostic indicators.
Background: Children in care and care leavers have worse health outcomes than their peers without care experience. This study addresses an evidence gap in exploring care-experienced young people's views and experiences of accessing general practice and dental services and attending health reviews in England.
Methods: We conducted a qualitative study using podcasting as a creative medium.
Introduction: The adoption of remote healthcare methods has been accelerated by the COVID-19 pandemic, but evidence suggests that some patients need additional support to engage remotely, potentially increasing health disparities if needs are not met. This study of COVID-19 remote home monitoring services across England explores experiences of and engagement with the service across different patient groups.
Methods: This was a mixed-methods study with survey and interview data collected from 28 services across England between February and June 2021.