Pain perception during colonoscopy in relation to gender and equipment: a clinical study.

Objectives A trend for gender-related differences in pain perception during colonoscopies has previously been observed. No consecutive clinical studies have been conducted to confirm such a relation. We aimed to investigate gender-related differences during the colonoscopy procedure, and the impact of endoscopic equipment and psychological factors on pain management.

MHC-I presentation of peptides derived from intact protein products of the pioneer round of translation.

Among the earliest protein products of most cellular genes are those synthesized during the pioneer round of translation (PRT), a key step in nonsense-mediated mRNA decay (NMD) that allows scanning of new transcripts for the presence of a premature termination codon (PTC). It has been demonstrated that at least some PRT degradation products can be targeted to major histocompatibility (MHC)-I presentation. To gain new insight into this putative PRT-to-MHC-I route, we have assembled 2 pairs of reporter genes so that the 2 genes in each pair encode an identical fusion protein between a model antigenic peptide and enhanced green fluorescent protein (EGFP), one of which harbors a PTC.

Colonoscopy results are not enhanced by use of magnet endoguide in specialist practice.

Introduction: It is discussed whether the use of a magnetic positioning device (OLYMPUS; UPD (unit of magnetic positioning device)) enhances the success of the colonoscopic procedure. Concern for patient compliance and endoscopic efficiency has been voiced in connection with the implementation of colon cancer screening. UPD has been proposed as a tool for optimization of results and reduction of patient discomfort.

Barrett's esophagus. Diagnosis, follow-up and treatment.

Barrett's Esophagus (BE) is a premalignant condition in the esophagus. Esophageal adenocarcinomas have the fastest increase of incidence of all solid tumors in the western world. BE is defined as areas with macroscopic visible columnar epithelium and intestinal metaplasia oral of the anatomical gastroesophageal junction.

Characterization of pedestrian accidents and an examination of infrastructure measures to improve pedestrian safety in Israel.

The high share of pedestrian fatalities in Israel provided the impetus for this study which looked for infrastructure solutions to improve pedestrian safety. First, a detailed analysis of pedestrian accidents in 2006-2007, with an emphasis on the infrastructure characteristics involved, was performed; it found that 75% of the fatalities and 95% of the injuries occurred in urban areas, the majority of cases occurring on road sections (not at junctions). About 80% of the accidents took place when a pedestrian crossed the road, the majority of them at non-crosswalk locations or at non-signalized crosswalks.