Publications by authors named "L Helman"
Metabolic syndrome (MS) is frequently associated with an increased body mass index (BMI), and related to an adverse cardiovascular prognosis. The purpose of this study is to evaluate the prevalence and association between MS, obesity and subclinical atherosclerosis (SA). This cross-sectional study included healthy adults, allocated to normal weight (NW) when BMI <25 kg/m, overweight (OW) BMI ≥25 and <30 kg/m, or obese (OB) BMI ≥30 kg/m groups.
View Article and Find Full Text PDFThe respiratory syncytial virus prefusion F protein vaccine attenuates the severity of respiratory syncytial virus-associated disease in breakthrough infections in adults ≥60 years of age.
Influenza Other Respir Viruses
February 2024
Article Synopsis
- RSV is a highly infectious virus that causes respiratory infections, with significant effects on older adults, and a candidate vaccine (RSVPreF3 OA) showed promising efficacy rates of 71.7% for ARIs and 82.6% for LRTD in adults 60 and older.
- In a phase 3 trial, participants aged 60 and above either received the RSVPreF3 OA vaccine or a placebo, with patient-reported outcomes evaluated through various health questionnaires.
- Results indicated that those vaccinated had significantly fewer RSV-ARI episodes and experienced milder symptoms compared to the placebo group, suggesting the vaccine can both prevent infections and lessen symptom severity.
Article Synopsis
- Antibodies targeting the insulin-like growth factor type 1 receptor (IGF-1R) can lead to temporary tumor responses in rhabdomyosarcoma (RMS), but combining them with dasatinib, an inhibitor of YES (a molecule linked to resistance), shows more promise.
- A phase I trial involved patients with aggressive forms of RMS, where they received the anti-IGF-1R antibody ganitumab alongside dasatinib, with dosages carefully adjusted to find the maximum tolerated dose.
- Results indicated that while the treatment was generally safe and tolerable, with a moderate disease control rate of 22% over five months, only a few patients experienced significant responses, suggesting the need for further
Data-driven basic, translational, and clinical research has resulted in improved outcomes for children, adolescents, and young adults (AYAs) with pediatric cancers. However, challenges in sharing data between institutions, particularly in research, prevent addressing substantial unmet needs in children and AYA patients diagnosed with certain pediatric cancers. Systematically collecting and sharing data from every child and AYA can enable greater understanding of pediatric cancers, improve survivorship, and accelerate development of new and more effective therapies.
View Article and Find Full Text PDFRespiratory Syncytial Virus Disease Burden in Community-Dwelling and Long-Term Care Facility Older Adults in Europe and the United States: A Prospective Study.
Open Forum Infect Dis
April 2023
Background: Data on respiratory syncytial virus (RSV) disease burden in adults remain scarce. We assessed the burden of confirmed RSV-acute respiratory infections (cRSV-ARIs) in community-dwelling (CD) adults and those in long-term care facilities (LTCFs).
Methods: In this prospective cohort study covering 2 RSV seasons (October 2019-March 2020 and October 2020-June 2021), RSV-ARIs were identified through active surveillance, in medically stable CD-adults ≥50 years (Europe) or adults ≥65 years in LTCFs (Europe and the United States).