Navigating the multifaceted intricacies of the Na-Cl cotransporter, a highly regulated key effector in the control of hydromineral homeostasis.

The Na-Cl cotransporter (NCC; SLC12A3) is a highly regulated integral membrane protein that is known to exist as three splice variants in primates. Its primary role in the kidney is to mediate the cosymport of Na and Cl across the apical membrane of the distal convoluted tubule. Through this role and the involvement of other ion transport systems, NCC allows the systemic circulation to reclaim a fraction of the ultrafiltered Na, K, Cl, and Mg loads in exchange for Ca and [Formula: see text].