Publications by authors named "L Hasselbach"
Article Synopsis
- Glioblastoma (GBM) tumors show diverse genetic and transcriptional profiles, leading to significant variations in how cancer stem cells (CSCs) respond to standard treatments like radiation and temozolomide (TMZ).
- Through targeted proteomics and RNA sequencing, the study found that while differentiating CSCs to an astrocytic state activates certain oncogenic pathways and retains some "stemness," it also increases resistance to TMZ treatment.
- The transcriptional response to treatments was largely influenced by the p53 status of the cells, revealing that both mutant and wild-type p53 models activated a DNA-damage related immune response, indicating potential pathways for improving GBM treatment strategies.
Article Synopsis
- Recurrence of meningiomas is hard to predict with current methods, making it important to find noninvasive ways to identify patients at risk of recurrence.
- This study examines DNA methylation in blood and tissue samples from 155 meningioma patients, discovering unique markers and utilizing artificial intelligence to create models for predicting recurrence.
- The findings suggest that using liquid biopsy could provide a reliable and noninvasive method for diagnosis and predicting outcomes in meningioma patients, enhancing personalized treatment strategies.
Cardiovascular diseases continue to be the most imminent health care problems in the western world, accounting for numerous deaths per year. Heart failure (HF), namely the reduction of left ventricular function, is one of the major cardiovascular disease entities. It is chronically progressing with relapsing acute decompensations and an overall grave prognosis that is little different if not worse than most malignant diseases.
View Article and Find Full Text PDFA 26-year-old male patient presented with left-sided pneumonia, endocarditis of the tricuspid and pulmonary valves and a pulmonary artery embolism. In 2004 a Ross operation was performed because of congenital aortic valve stenosis. There was an elevation of the antibody titer for Coxiella burnetii, the pathogen of Q fever.
View Article and Find Full Text PDFThe impact of initial tumor microenvironment on imaging phenotype.
Cancer Treat Res Commun
December 2021
Models of human cancer, to be useful, must replicate human disease with high fidelity. Our focus in this study is rat xenograft brain tumors as a model of human embedded cerebral tumors. A distinguishing signature of such tumors in humans, that of contrast-enhancement on imaging, is often not present when the human cells grow in rodents, despite the xenografts having nearly identical DNA signatures to the original tumor specimen.
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