Publications by authors named "L Harinantenaina Rakotondraibe"
Peroxisomes are versatile eukaryotic organelles essential for many functions in fungi, including fatty acid metabolism, reactive oxygen species detoxification, and secondary metabolite biosynthesis. A suite of Pex proteins (peroxins) maintains peroxisomes, while peroxisomal matrix enzymes execute peroxisome functions. Insertional mutagenesis identified peroxin genes as essential components supporting the intraphagosomal growth of the fungal pathogen .
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- Researchers isolated five new compounds called omphalines A-E from the leaves and twigs of Omphalea oppositifolia, along with a known compound using chromatography methods.
- Omphaline A's structure was identified as a specific type of diterpenoid, characterized by unique double bonds and hydroxy groups.
- The absolute configuration of omphaline A was confirmed by comparing its experimental electronic circular dichroism (ECD) spectrum with calculated ones.
Research progress from mainly over the last five years is described for a multidisciplinary collaborative program project directed toward the discovery of potential anticancer agents from a broad range of taxonomically defined organisms. Selected lead compounds with potential as new antitumor agents that are representative of considerable structural diversity have continued to be obtained from each of tropical plants, terrestrial and aquatic cyanobacteria, and filamentous fungi. Recently, a new focus has been on the investigation of the constituents of U.
View Article and Find Full Text PDFRecent reports suggest that glucocorticoids (GCs), which can be synthesized in the oral mucosa, play an important role in cancer development. Therefore, the objectives of this study were to characterize the role of the oral GC system in oral cancer, and determine the effect of black raspberry (BRB) administration on GC modulation during oral cancer chemoprevention. We determined the expression of GC enzymes in various oral cancer cell lines, and investigated the role of the GC inactivating enzyme HSD11B2 on CAL27 oral cancer cells using siRNA mediated knockdown approaches.
View Article and Find Full Text PDFBackground/aim: Effect of capsicodendrin on the NF-κB pathway was studied in MCF-7 cancer cells.
Materials And Methods: The transcription factor assay was used to screen for NF-κB activity. The effect on IKKβ, ICAM-1, and caspase-7 were studied using western blot.