Effectiveness of appliance therapy in reducing overjet and open bite associated with thumb sucking habit.

Aim: The aim of this paper was to compare the effectiveness of appliance therapy and reward therapy in reducing overjet and open bite associated with thumb sucking habit.

Methods: Thirty nine subjects (17 males and 22 females) with chronic thumb sucking habit were allocated to three groups: group A (positive reinforcement), group B (modified triple loop corrector), and group C (control). Pre-treatment and post-treatment study casts were evaluated for changes in overjet and open bite.

Macromolecular intravenous contrast agent for MR lymphography: characterization and efficacy studies.

Purpose: To determine the pharmacokinetic and magnetic resonance (MR) imaging properties of diethylenetriaminepentaacetic acid (DTPA) conjugated with a polyglucose-associated macrocomplex (PGM), which accumulates in lymph nodes.

Materials And Methods: In 124 normal and 20 tumor-bearing rats, Gd-DTPA PGM was administered intravenously in doses of 2, 10, 20 mumol gadolinium per kilogram of tissue.

Results: Mean blood half-life was 2 hours.

MR lymphography with a lymphotropic T1-type MR contrast agent: Gd-DTPA-PGM.

A model system of a paramagnetic lymphotropic MR contrast agent (Gd-DTPA labeled polyglucose associated macrocomplex, PGM) for T1-weighted MR imaging of lymph nodes in rats and rabbits was evaluated. Pharmacokinetic (tissue accumulation) and MR imaging data (optimal dose and timing parameters) were obtained in normal rats (n = 88) after subcutaneous (SC) injection of paramagnetic, radiolabeled [111In]Gd-DTPA-PGM. A rabbit model of lymph node metastases (n = 8) was ultimately used to demonstrate the potential of MR imaging with Gd-DTPA-PGM for nodal tumor detection.