Publications by authors named "L Hanley"
The spatial distribution of organics in geological samples can be used to determine when and how these organics were incorporated into the host rock. Mass spectrometry (MS) imaging can rapidly collect a large amount of data, but ions produced are mixed without discrimination, resulting in complex mass spectra that can be difficult to interpret. Here, we apply unsupervised and supervised machine learning (ML) to help interpret spectra from time-of-flight-secondary ion mass spectrometry (ToF-SIMS) of an organic-carbon-rich mudstone of the Middle Jurassic of England (UK).
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- Microbially induced corrosion (MIC) affects environmental issues, such as interactions with radioactive waste and the role of microbes in environmental cleanup.
- A step-by-step protocol for preparing bacterial biofilms for analysis using time-of-flight secondary ion mass spectrometry (ToF-SIMS) is discussed, comparing three techniques: no desalination, centrifugal spinning (CS), and water submersion (WS).
- Results show that CS significantly reduces media peaks and enhances biological signals, revealing chemical changes in glass exposed to a specific bacterial biofilm over three months, indicating MIC effects.
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- High grade serous ovarian cancer (HGSOC) is a deadly gynecologic cancer that shows limited response to existing immunotherapies, highlighting the need for new immune targets, particularly focusing on the role of mast cells which increase after chemotherapy treatment.
- The study utilized immunohistochemistry methods to analyze mast cell levels in 36 HGSOC patient tumors before and after neoadjuvant chemotherapy (NACT), revealing significant changes in mast cell populations and their association with clinical outcomes.
- Results indicated that higher mast cell levels post-NACT were linked to poorer patient survival outcomes, with specific forms of mast cells (Tryptase+/CPA3+) showing a strong correlation with overall survival rates.
Background: Attention Deficit-Hyperactive Disorder (ADHD) is a neurodevelopmental disorder, often persisting into adulthood.
Aims: To investigate the levels of functionality and quality of life (QoL) in adult patients newly diagnosed with ADHD and to compare with those without an ADHD diagnosis.
Methods: Consecutive patients who were referred to and assessed in a tertiary adult ADHD clinic enrolled in the study.
In many healthcare settings, teams change composition regularly, so healthcare students must be trained to function effectively in dynamic teams before entering the workforce. Interprofessional clinical rotations provide an ideal venue for learners to practice these skills, but little is known about how student teams interact in such settings. In this qualitative observational evaluation, learners from multiple health professions at a single institution participated in scheduled clinics in low-income housing communities for older adults.
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