Publications by authors named "L Haddow"
Introduction: Accurate risk scoring in emergency general surgery (EGS) is vital for consent and resource allocation. The emergency surgery score (ESS) has been validated as a reliable preoperative predictor of postoperative outcomes in EGS but has been studied only in the US population. Our primary aim was to perform an external validation study of the ESS in a UK population.
View Article and Find Full Text PDFEffects of Sex Hormones on Vascular Reactivity in Boys With Hypospadias.
J Clin Endocrinol Metab
January 2024
Article Synopsis
- Boys with hypospadias show abnormal artery responses, like hypercontractility and decreased ability to relax, and the influence of sex hormones on these issues is not fully understood.
- The study aimed to investigate how sex steroids affect blood vessel behavior in healthy boys versus those with hypospadias using artery samples from surgeries.
- Results indicated that in healthy boys, sex hormones cause increased vasoconstriction, whereas in boys with hypospadias, these hormones actually reduce vasoconstriction and assist in vasorelaxation, suggesting hormone effects may vary based on existing vascular conditions.*
Surveillance of Mpox Cases Attending Sexual Health Services in England (SOMASS): design, implementation and initial findings from the SOMASS data collection tool, 2022.
Sex Transm Infect
November 2023
Objectives: We aimed to design and implement a data collection tool to support the 2022 mpox (monkeypox) outbreak, and to describe clinical and epidemiological data from individuals with mpox attending sexual health services (SHSs) in England.
Methods: The UK Health Security Agency and the British Association for Sexual Health and HIV established the Surveillance of Mpox Cases Attending Sexual Health Services in England (SOMASS) system.Descriptive data were collected via a secure web-based data collection tool, completed by SHS clinicians following consultation with individuals with suspected mpox.
Background: People with HIV have an increased risk for cardiovascular morbidity and mortality. Inflammation and immune activation may contribute to this excess risk.
Methods: We assessed thirty-one biomarkers in a subset of POPPY participants and identified three distinct inflammatory profiles: 'gut/immune activation', 'neurovascular', and 'reference' (relatively low levels of inflammation).