Horse Diagnosis and Triage Accuracy of GPT-4o.

Animal owners may increasingly rely on large language models for gathering animal health information alongside internet sources in the future. This study therefore aims to provide initial results on the accuracy of ChatGPT-4o in triage and tentative diagnostics, using horses as a case study. Ten test vignettes were used to prompt situation assessments from the tool, which were then compared to original assessments made by a veterinary specialist for horses.

Comparative outcomes of operative treatment for two and three-part proximal humerus fractures with or without ipsilateral shaft fractures and head-split patterns: intramedullary nail versus open reduction internal fixation.

Purpose: To investigate whether the outcomes, including union rates, complications, reoperations, blood loss, operative time, and range of motion, differed following intramedullary nailing (IMN) or open reduction internal fixation (ORIF) of two- and three-part proximal humerus fractures with or without ipsilateral shaft fractures and head-split patterns.

Methods: This was a retrospective multicenter study at three community centers and one level 1 trauma center. Inclusion criteria were two- and three-part proximal humerus fracture treated with either IMN or ORIF from 2015 to 2022 with at least three months of postoperative follow-up.

Itaconate promotes an unexpected tumor immune escape mechanism.

Itaconate is a metabolite produced by macrophages upon infection and acts as an antimicrobial molecule. In this issue of Cancer Cell, Lin et al. find that itaconate produced by tumor-associated macrophages is taken up by cancer cells via the transporter solute carrier family 13 member 3 (SLC13A3), promoting resistance to immune checkpoint inhibitors.

Designing an mHealth Application to Support Horse Owners in Assessing Their Horse's Health Status - Results of a Usability Test.

Introduction: Existing research agrees that a well-thought design of the user interface is a key point for an mHealth application for animal owners, supporting them obtain information and make decisions regarding their pet's specific situation. However, there is currently a lack of specific advice on the design of such an application.

Methods: As part of a user-centered design (UCD) process, a formative, explorative usability test with n = 5 users was conducted for collecting design ideas.

Tranexamic Acid in Total Shoulder Arthroplasty: A Scoping Review of Current Practices and Future Directions.

Background: The effectiveness of tranexamic acid (TXA) as an antifibrinolytic agent in total shoulder arthroplasty (TSA) is well documented; however, there remains considerable practice variability concerning the optimal route of administration and dosing protocols concerning the medication's use. Our aim was to conduct a scoping review of the literature regarding the efficacy of various methods of TXA administration in TSA and to identify knowledge gaps that may be addressed.

Methods: A scoping review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews guidelines.