Publications by authors named "L HOLLANDER"
The mechanisms underlying the remarkable capacity of the liver to regenerate are still not completely understood. Particularly, the cross-talk between cytokines and cellular components of the process is of utmost importance because they represent potential avenues for diagnostics and therapeutics. WNT1-inducible-signaling pathway protein 1 (WISP1) is a cytokine member of the CCN family, a family of proteins that play many different roles in liver pathophysiology.
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- The COVID-19 pandemic affected children's physical activity levels, which have only partially rebounded to pre-pandemic numbers, with 41% still not meeting activity guidelines in the UK.
- A study involving interviews and focus groups revealed themes including increased screen time, disrupted social and emotional development, and mental health challenges for families, leading to increased barriers for children's activity.
- The findings suggest a "new normal" for children's physical activity characterized by structured activities, with particular concerns for girls and children from lower socio-economic backgrounds facing more significant challenges.
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- Patients with refractory myeloid malignancies have a poor prognosis, and traditional allogeneic hematopoietic cell transplantation (HCT) with myeloablative conditioning (MAC) has high relapse and mortality rates.
- A new MAC regimen combining clofarabine and busulfan (Clo/Bu4) shows promise, especially for patients up to 70 years old, with a retrospective study identifying positive outcomes in a real-world setting.
- Among 69 patients treated between 2012 and 2020, those with acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS) achieved notable event-free survival rates, with 72.5% in complete remission at day 100 post-transplant
Background: Although programmed cell death protein 1 (PD-1) inhibitors have revolutionised treatment for advanced melanoma, not all patients respond. We previously showed that inhibition of the flavoprotein renalase (RNLS) in preclinical melanoma models decreases tumour growth. We hypothesised that RNLS inhibition promotes tumour rejection by effects on the tumour microenvironment (TME).
View Article and Find Full Text PDFWe investigated whether naturally acquired maternal antibodies to epizootic hemorrhagic disease virus serotype 2 (EHDV-2) would protect white-tailed deer (Odocoileus virginianus) fawns against infection and clinical disease following an EHDV-2 challenge. We compared viremia and clinical response in 27-47-d-old, experimentally infected fawns with and without maternally derived antibodies to EHDV-2. Mild to moderate clinical signs were observed in four seronegative (maternal antibody-negative) fawns, which were viremic from 3 to 14 d postinoculation.
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