Background: Morbid obesity is associated with aging of the immune system, a phenomenon known as "inflammaging," characterized by increased numbers of various immune cell subsets.
Objectives: To evaluate the long-term effects of bariatric surgery on immune cell subsets in patients with obesity and to determine the impact of metabolic syndrome on these changes.
Setting: High-volume bariatric center, Netherlands.
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View Article and Find Full Text PDFMorbid obesity is associated with a chronic state of low-grade inflammation, which may lead to accelerated differentiation of T and B cells. These differentiated immune cells are strongly cytotoxic and have an increased pro-inflammatory cytokine producing capacity. Furthermore, the anti-inflammatory function of the T and B cells decreases.
View Article and Find Full Text PDFBackground: Insufficient weight loss or weight regain has many causes including a large gastric pouch. A large gastric pouch may be due to the surgical technique or can be patient related (dilation). Resizing the gastric pouch may lead to additional weight loss.
View Article and Find Full Text PDFMorbid obesity is characterized by chronic, low-grade inflammation, which is associated with 'inflamm-aging'. The presence of metabolic syndrome (MetS) might accelerate this phenomenon of metaflammation. In this study, we assessed the effects of morbid obesity and MetS on the composition of a broad spectrum of immune cells present within the circulation.
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