Social capital and maternal mental health: Findings from secondary data analyses of two linked longitudinal trials in Australia.

Problem: Low social capital has been identified as an important risk factor in the development of postpartum mental illness.

Background: Evidence suggests that new and expectant mothers with higher levels of support have lower rates of maternal mental illness, yet few studies examine this relationship longitudinally.

Aim: This study investigated the association between social capital in late pregnancy and maternal mental health up to 5 years postpartum.

Efficient Production of Recombinant Human Brain-Derived Neurotrophic Factor in Through the Engineering of Its Pro-Region.

Thus far, no manufacturing process able to support industrialization has been reported for the recombinant human brain-derived neurotrophic factor (rhBDNF). Here, we described the setup of a new protocol for its production in () and its purification to homogeneity. A synthetic gene, codifying for the neurotrophin precursor, was inserted into an expression vector and transformed into BL21 (DE3) strain.

Shining a spotlight on pulmonary hypertension associated with interstitial lung disease care: The latest advances in diagnosis and treatment.

Pulmonary hypertension associated with interstitial lung disease (PH-ILD) is a complex condition in which 2 consequential diseases interact and increase negative outcomes. Although the pathophysiologic mechanisms of PH-ILD are not yet well understood, the pronounced effect on functional status, supplemental oxygen requirements, health care resource utilization, and mortality that frequently accompany this diagnosis are well documented. A critical feature that complicates pathophysiologic understanding of PH-ILD is that progression of the pulmonary vascular disease does not always appear to be driven by the underlying lung disease.

The role of the Latin American Professional Society of Genetic Counseling (SPLAGen): Advancing genetic counseling in Latin America.

The increasing importance of genomics and its expanding clinical application underscore the significance of genetic counseling in disseminating this vital information. In many countries, including regions of Latin America and the Caribbean, there is a shortage of adequately trained genetics providers thus limiting access to these essential services. Moreover, providers practicing genetic counseling are scarce and experience a lack of professional support.

Genetic variants in DDX53 contribute to autism spectrum disorder associated with the Xp22.11 locus.

Autism spectrum disorder (ASD) exhibits an ∼4:1 male-to-female sex bias and is characterized by early-onset impairment of social/communication skills, restricted interests, and stereotyped behaviors. Disruption of the Xp22.11 locus has been associated with ASD in males.