Advances in Canine Anesthesia: Physiologically Based Pharmacokinetic Modeling for Predicting Propofol Plasma Profiles in Canines with Hepatic Impairment.

: A PBPK model allows the prediction of the concentration of drug amounts in different tissues and organs over time and can be used to simulate and optimize different therapeutic protocols in healthy and sick individuals. The objective of this work was to create a PBPK model to predict propofol doses for healthy canines and canines with hepatic impairment. : The study methodology was divided into two major phases, in which the first phase consisted of creating the PBPK model for healthy canines, and in the second phase, this model was adjusted for canines with hepatic impairment.

L-Arginine Supplementation Did Not Impact the Rapid Recovery of Cardiovascular and Autonomic Function Following Exercise in Physically Active Healthy Males: A Triple-Blind Randomised Placebo-Controlled Crossover Trial.

Background And Aims: Post-exercise recovery strategies include massage, low-intensity active exercise, thermal contrast, hydration, and nutritional and herbal approaches. These strategies aim to accelerate recovery, enhance performance, and optimise the physical training process. L-arginine (L-ARG) is the physiological precursor of nitric oxide (NO), a crucial mediator of vasodilation and the inhibition of platelet aggregation.

A new cicada (Hemiptera: Cicadidae) species from Brazil with a detailed description of the genus Parnisa Stål, 1862 and key to the known species.

The new cicada species Parnisa infuscata sp. nov. is described, along with its calling song, from Minas Gerais State in Brazil.

Impact of pre-fermentative maceration techniques on the chemical characteristics, phenolic composition, in vitro bioaccessibility, and biological activities of alcoholic and acetic fermented products from jaboticaba (Plinia trunciflora).

The jaboticaba is a fruit with a highly promising chemical profile for producing fermented products with biological activity. In this context, evaluating pre-fermentative maceration techniques in jaboticaba fermentations is essential to optimize the extraction of phenolic compounds and other metabolites of interest, imparting antioxidant characteristics to the product and offering potential health benefits. This study evaluated the impact of two pre-fermentative maceration techniques on the phenolic composition, bioaccessibility, and biological activities (α-amylase, α-glucosidase, and ACE inhibition) of alcoholic and acetic fermented products from jaboticaba.

A computer-assisted endodontic access technique to remove fiber posts.

Clinical treatments employing a 3-dimensional computer-assisted endodontic access technique (CEAT-3D) to remove fiber posts from posterior teeth in a minimally invasive manner using computer-aided design and computer-aided manufacturing (CAD-CAM) technology are described. Three patients with symptomatic molars and periapical radiolucency and with different treatment complexities had been referred for endodontic retreatment. For the removal of the fiber posts and endodontic retreatment, 3-dimensionally printed guides were designed from intraoral and cone beam computed tomography (CBCT) scans with a digital planning software program.