The role of the C-terminus for functional heteromerization of the plant channel KDC1.

Voltage-gated potassium channels are formed by the assembly of four identical (homotetramer) or different (heterotetramer) subunits. Tetramerization of plant potassium channels involves the C-terminus of the protein. We investigated the role of the C-terminus of KDC1, a Shaker-like inward-rectifying K(+) channel that does not form functional homomeric channels, but participates in the formation of heteromeric complexes with other potassium alpha-subunits when expressed in Xenopus oocytes.

Noninclusion-body infantile digital fibromatosis: a lesion heralding terminal osseous dysplasia and pigmentary defects syndrome.

This report describes the histologic and immunohistochemical features of a peculiar type of digital fibroma that shares some clinical and microscopic features with the more common inclusion-body type infantile digital fibromatosis. However, this type does not exhibit inclusion bodies and its cells are reactive for vimentin but not for actin. Significantly, it presents in combination with a constellation of other clinical findings, i.

[Multiple applications of closed permanent wet dressings. Their mode of action].

New applications and forms of Darier's humid permanent closed cures are analysed specially in connection with concepts of cutaneous hydratation. The multiplicity of their application however makes it necessary to find an explanation for their excellent effects which are probably related to the anti-inflammatory, antipruritic and antiinfectious actions as well as the permanent draining effect from the deeper layers to the surface of the epidermis. The hydratation affected by HPCC is very important in dry and exudative stasis dermatitis with both a complete or a partial loss of stratum corneum.