Publications by authors named "L H Pao"
Regulatory T cells (Tregs) are critical mediators of immune tolerance and play a diametric role in cancer and autoimmunity. Tumor-infiltrating Tregs are often associated with poor prognosis in solid tumors because their enrichment in the tumor microenvironment contributes to immunosuppression. Conversely, dysregulation in the Treg compartment can disrupt self-tolerance, leading to autoimmunity.
View Article and Find Full Text PDFMonkeypox (mpox) cases in the 2022 outbreak have primarily occurred among adult gay, bisexual, and other men who have sex with men (MSM); however, other populations have also been affected (1). To date, data on mpox in cisgender women and pregnant persons have been limited. Understanding transmission in these populations is critical for mpox prevention.
View Article and Find Full Text PDFArticle Synopsis
- As of November 2022, over 28,000 monkeypox cases were reported in the U.S., primarily among adult cisgender men engaging in male-to-male sexual contact.
- Transgender and gender-diverse individuals, who make up about 0.5% of the adult population, were disproportionately affected, with 466 cases (1.7% of adult cases) reported during a specific timeframe.
- Most mpox cases in this group were among transgender women and gender-diverse persons, highlighting the need for targeted public health strategies to address the unique health disparities they face.