Publications by authors named "L H Opie"
Article Synopsis
- - The MET receptor is crucial for various biological processes, but its dysregulation is linked to cancers like non-small cell lung cancer and renal cancer, highlighting a significant medical need for better treatment options.
- - Current MET inhibitors face challenges such as resistance and toxicity, particularly in treating brain metastases, which further emphasizes the demand for improved therapies.
- - Researchers are developing a new class of MET inhibitors designed to effectively target brain tumors and specific cancer mutations, which showed promising results in preclinical models, significantly extending survival in treated animals.
Aims: Acute heart failure (AHF) is a burden disease, with high mortality and re-hospitalisations. Using an ex-vivo model of AHF, we have previously reported that sphingosine-1-phosphate (S1P) confers cardioprotection. However, the mechanisms remain to be elucidated.
View Article and Find Full Text PDFBackground: Beta-blockers refer to a mixed group of drugs with diverse pharmacodynamic and pharmacokinetic properties. They have shown long-term beneficial effects on mortality and cardiovascular disease (CVD) when used in people with heart failure or acute myocardial infarction. Beta-blockers were thought to have similar beneficial effects when used as first-line therapy for hypertension.
View Article and Find Full Text PDFMelatonin, widely used to counter transatlantic travel jet lag and insomnia, is synthesized in the suprachiasmatic nucleus of the anterior pituitary gland. Its release into the circulation is stimulated by the onset of darkness, followed by a progressive decrease in blood levels with the onset of dawn. Melatonin administration can maintain the quality of sleep and help to counteract age-induced cognitive decline.
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