An evolutionary continuum from nucleated dwarf galaxies to star clusters.

Systematic studies have revealed hundreds of ultra-compact dwarf galaxies (UCDs) in the nearby Universe. With half-light radii r of approximately 10-100 parsecs and stellar masses M≈ 10-10solar masses, UCDs are among the densest known stellar systems. Although similar in appearance to massive globular clusters, the detection of extended stellar envelopes, complex star formation histories, elevated mass-to-light ratio and supermassive black holes suggest that some UCDs are remnant nuclear star clusters of tidally stripped dwarf galaxies, or even ancient compact galaxies.

Embedding routine health checks for adults with intellectual disabilities in primary care: practice nurse perceptions.

Background: Adults with intellectual disabilities (IDs) have consistently poorer health outcomes than the general population. There is evidence that routine health checks in primary care may improve outcomes. We conducted a randomised controlled trial of practice nurse led health checks.

Plasma phospholipids identify antecedent memory impairment in older adults.

Alzheimer's disease causes a progressive dementia that currently affects over 35 million individuals worldwide and is expected to affect 115 million by 2050 (ref. 1). There are no cures or disease-modifying therapies, and this may be due to our inability to detect the disease before it has progressed to produce evident memory loss and functional decline.

Expression of Voltage-Gated Sodium Channel Na1.8 in Human Prostate Cancer is Associated with High Histological Grade.

Voltage-gated sodium (Na) channels are required for impulse conductance in excitable tissues. Nas have been linked to human cancers, including prostate. The expression and distribution of Na isoforms (Na1.

Network modeling to identify new mechanisms and therapeutic targets for Parkinson's disease.

Biomolecules in subnetworks are the focus of a new strategy to develop drugs that halt complex diseases. In this article, the authors use genome-wide association study and linkage data derived from Parkinson's disease studies to illustrate how algorithms that use gene and protein interaction databases reveal subnetworks in biological systems that suggest mechanisms for disease progression. Network modeling may help develop testable hypotheses for neurodegenerative diseases and open up new avenues for therapeutic development.