Copper-Mediated Enantioselective C-H Thiolation of Ferrocenes Enabled by the BINOL Ligand.

Transition-metal-catalyzed enantioselective C-H activation has transformed the landscape of asymmetric synthesis, enabling the efficient conversion of C-H bonds into C-C and carbon-heteroatom (C-X) bonds. However, the formation of C-S bonds through enantioselective C-H thiolation remains underdeveloped due to challenges such as catalyst deactivation and competitive coordination of sulfur-containing compounds with chiral ligands. Herein, we report an unprecedented approach to constructing sulfur-substituted planar chiral ferrocenes (PCFs) through copper-mediated enantioselective C-H thiolation enabled by only a 2.

Duck feather inspired hydrophobic carboxymethyl cellulose/gelatin film for intelligent and active food packaging.

Inspired by the superhydrophobic characteristics of duck feathers this research introduced an intelligent, responsive, and eco-friendly food packaging film constructed from carboxymethyl cellulose (CMC) and gelatin (Gel). The film successfully mimics the asymmetric, bionic, barbed structure of a duck feather, offering outstanding hydrophobicity and moisture vapor resistance characteristics. Moreover, the bionic film demonstrated good mechanical strength, film-forming ability and biodegradability.

Temperature-driven CsgA-enhanced mutant enable distinct self-assembly.

Functional coating materials have found extensive applications across various technological fields. However, the effectiveness of these coating depends critically on the choice of an appropriate medium. In this study, we developed an advanced "molecular glue", a CsgA variant known as CsgA-pro, which can serve as a versatile medium for biotherapy.

PD(L)1 Inhibitors Plus Lenvatinib Vs Atezolizumab Plus Bevacizumab Combined With HAIC for Unresectable HCC: A Propensity Score Matching Study.

Purpose: To compare the clinical outcomes of different systemic therapies, specifically PD(L)1 inhibitors plus Lenvatinib versus Atezolizumab plus Bevacizumab, when combined with hepatic arterial infusion chemotherapy (HAIC) based on the FOLFOX regimen (oxaliplatin, fluorouracil, and leucovorin) as first line treatment for unresectable hepatocellular carcinoma.

Patients And Methods: This real-world retrospective study enrolled 294 patients with unresectable HCC. All patients received HAIC in combination with either PD(L)1 inhibitors plus Lenvatinib (PLEN-HAIC) or Atezolizumab plus Bevacizumab (AT-HAIC).

Identification of key miRNAs and target genes in extracellular vesicles derived from low-intensity pulsed ultrasound-treated stem cells.

Objectives: This study aimed to investigate the impact of low-intensity pulsed ultrasound (LIPUS) treatment on the miRNA and mRNA profiles of stem cell-derived extracellular vesicles (EVs). Specifically, it sought to identify key miRNAs and their target mRNAs associated with enhanced therapeutic efficacy in LIPUS-treated stem cell-derived EVs.

Methods: Utilizing miRNA deep-sequencing data from the Gene Expression Omnibus database, differential gene analysis was performed.