Tropical Indian Ocean drives Hadley circulation change in a warming climate.

The weakening and poleward expansion of the Hadley circulation (HC) are considered robust responses of atmospheric meridional circulation to anthropogenic warming. Climate impacts arising from these changes enhance drought conditions and reduce food production in the affected regions. Therefore, understanding the mechanisms of HC changes is critical to anticipating the resultant climate risks.

Temporal and spatial variations of urban surface temperature and correlation study of influencing factors.

Urban overheating significantly affects thermal comfort and livability, making it essential to understand the relationship between urban form and land surface temperature (LST). While the horizontal dimensions of urban form have been widely studied, the vertical structures and their impact on LST remain underexplored. This study investigates the influence of three-dimensional urban form characteristics on LST, using ECOSTRESS sensor data and four machine learning models.

Lipid metabolic remodeling delays senescence of T cells to potentiate their immunity against solid tumors.

Background: Tumor cells can drive the senescence of effector T cells by unbalancing their lipid metabolism, thereby limiting adoptive T cell therapy and contributing to tumor immune evasion. Our objective is to provide a feasible strategy for enhancing T cell treatment efficacy against solid tumors.

Methods: In this study, liposomal arachidonyl trifluoromethyl ketone (ATK) was anchored onto the adoptive T cell surface via bioorthogonal reactions, aiming to specifically inhibit the group IVA cytosolic phospholipase Aα (cPLAα), a key enzyme facilitating phospholipid metabolism and senescent state of T cells.

Elevated p16Ink4a Expression Enhances Tau Phosphorylation in Neurons Differentiated From Human-Induced Pluripotent Stem Cells.

Increased expression of the cyclin-dependent kinase inhibitor p16Ink4a (p16) is detected in neurons of human Alzheimer's disease (AD) brains and during normal aging. Importantly, selective eliminating p16-expressing cells in AD mouse models attenuates tau pathologies and improves cognition. But whether and how p16 contributes to AD pathogenesis remains unclear.