Bioactive Compounds from Propolis on Bone Homeostasis: A Narrative Review.

This narrative review explores the potential effects of Propolis and its bioactive compounds on bone health. Propolis, a resinous product collected by bees, is renowned for its antimicrobial, anti-inflammatory, and antioxidant properties. Recent research emphasizes its positive role in osteogenesis, primarily through the modulation of osteoclast and osteoblast activity via molecular pathways.

Combined Association of Plasma Metabolites with Body Mass Index and Physical Activity Level.

Metabolomic analysis of the changes in plasma metabolites in obesity along with physical activity interaction may contribute to disease diagnosis and treatment. We sought to make a comprehensive assessment of the plasma metabolite profile of subjects with a lean ( = 20, BMI = 22.3) or overweight/obese ( = 29, BMI = 29) body mass index (BMI) and low ( = 33, IPAQ = 842) or high ( = 16, IPAQ = 6935) index of physical activity questionnaire (IPAQ), using an untargeted metabolomic approach.

Metabolomics analyses and physical interventions in soccer: a systematic review.

Background: Soccer is the most recognized sports worldwide. It is a fertile ground for the use of metabolomics analyses, considering the multifactorial nature of soccer's physical demands on the body. Although scientific studies have tried using it to better understand the impacts of soccer into different contexts of the sport, no systematic review is available on metabolomics analyses in soccer athletes subjected to physical exertion interventions.

Multimodal single-cell profiling reveals neuronal vulnerability and pathological cell states in focal cortical dysplasia.

Focal cortical dysplasia (FCD) is a neurodevelopmental condition characterized by malformations of the cerebral cortex that often cause drug-resistant epilepsy. In this study, we performed multi-omics single-nuclei profiling to map the chromatin accessibility and transcriptome landscapes of FCD type II, generating a comprehensive multimodal single-nuclei dataset comprising 61,525 cells from 11 clinical samples of lesions and controls. Our findings revealed profound chromatin, transcriptomic, and cellular alterations affecting neuronal and glial cells in FCD lesions, including the selective loss of upper-layer excitatory neurons, significant expansion of oligodendrocytes and immature astrocytic populations, and a distinct neuronal subpopulation harboring dysmorphic neurons.

Transcutaneous intravascular laser irradiation of blood affects plasma metabolites of women.

The effectiveness of indirect Intravascular laser irradiation of blood (ILIB) is not fully understood. In this study, we provided a novel experiment that employs metabolomics to investigate the effects of ILIB in women. Twenty-eight volunteers underwent indirect ILIB and had their plasma collected before and after this procedure.