Cardiac function and coronary plaque development following masculinizing gender-affirming hormone therapy: A prospective cohort study.

Introduction: Myocardial dysfunction and the presence of calcified and non-calcified coronary plaques are predictors of cardiovascular disease. Masculinizing gender-affirming hormone therapy may increase cardiovascular risk, highlighting the need for prospective studies to evaluate cardiovascular outcomes during gender-affirming hormone therapy.

Objectives: To evaluate changes in cardiac morphology, systolic and diastolic function, and development of coronary plaques after masculinizing gender-affirming hormone therapy.

Potential nuances in renoprotective properties of estrogen in females.

A current study by Kitai et al. found that ovariectomy before estrogen/female sex hormone sensitization at puberty provided protection against kidney ischemia reperfusion injury, challenging the general consensus within the field that estrogen provides renoprotective function. These results are intriguing and could have important clinical implications, while requiring some clarification and substantiation of the conclusions reported.

Comparison of Adaptive and Nonadaptive Gap Detection in Noise Test in Typically Developing Children and Adults.

Purpose:  The purpose of this study is to examine whether the gap detection thresholds (GDT) obtained are similar between an adaptive and nonadaptive procedure in children and adults.

Study Design:  Standard group comparison.

Study Sample:  Eighteen typically developing children and 20 young adults with hearing thresholds of 25 dB HL or lower participated in this study.

Efficacy and Safety of Fluocinolone Acetonide 0.19 mg Intravitreal Implant for the Treatment of Non-Infectious Uveitis: A Systematic Review of Real-World Evidence.

This systematic review evaluates the real-world efficacy and safety of the 0.19 mg fluocinolone acetonide (FAc) sustained-release intravitreal implant for treating non-infectious uveitis affecting the posterior segment of the eye (NIU-PS). Following PRISMA guidelines, a search was conducted in PubMed, Embase and Web of Science, with the latest update on September 20, 2024.

Management of twin-reversed arterial perfusion (TRAP) sequence: a systematic review and meta-analysis.

Introduction: Twin reversed arterial perfusion (TRAP) sequence is a rare complication of monochorionic twin pregnancies characterized by placental anastomoses between a normally developed twin and an acardiac mass. Though several treatment modalities exist, the optimal management strategy is unclear. This study aims to compare the various treatment strategies for TRAP sequence.