The Use and Efficacy of Biological Therapies for Inflammatory Bowel Disease in a Danish Tertiary Centre 2010-2020.

Background: Patients with inflammatory bowel disease (IBD) who receive biologicals frequently experience lack or loss of response. Our aim was to describe the use and efficacy of biological therapy in a tertiary IBD center.

Methods: We included all bio-naive IBD patients who initiated biological therapy between 2010 and 2020 at our centre.

VPint: value propagation-based spatial interpolation.

Given the common problem of missing data in real-world applications from various fields, such as remote sensing, ecology and meteorology, the interpolation of missing spatial and spatio-temporal data can be of tremendous value. Existing methods for spatial interpolation, most notably Gaussian processes and spatial autoregressive models, tend to suffer from (a) a trade-off between modelling local or global spatial interaction, (b) the assumption there is only one possible path between two points, and (c) the assumption of homogeneity of intermediate locations between points. Addressing these issues, we propose a value propagation-based spatial interpolation method called VPint, inspired by Markov reward processes (MRPs), and introduce two variants thereof: (i) a static discount (SD-MRP) and (ii) a data-driven weight prediction (WP-MRP) variant.

Psychiatric Disorders in Adult and Paediatric Patients With Inflammatory Bowel Diseases - A Systematic Review and Meta-Analysis.

Background: Inflammatory bowel diseases [IBD], which are associated with a high disease burden, are also reported to be accompanied by a high prevalence of psychiatric disorders. However, the literature on IBD and psychiatric disorders has not been reviewed.

Methods: This systematic review followed the PRISMA guidelines, and its protocol was registered at PROSPERO [ID: CRD42020214359].

Comparative fate of CrAssphage with culturable and molecular fecal pollution indicators during activated sludge wastewater treatment.

Wastewater treatment plants are typically monitored using fecal indicator bacteria to ensure adequate microbial water quality of the treated effluent. Fecal indicator bacteria exhibit poor correlation with virus fate in the environment, including during wastewater treatment. Viral-based microbial source tracking methods have the potential to overcome this limitation.

Subchronic toxicity study of β-hydroxy-β-methylbutyric free acid in Sprague-Dawley rats.

Calcium β-hydroxy-β-methylbutyrate-monohydrate (CaHMB) is a dietary supplement used as an ergogenic aid and in functional and medical foods. A new delivery form has been developed, β-hydroxy-β-methylbutyric free acid (HMBFA), which has improved bioavailability. While the safety of CaHMB is well documented, there are few published studies demonstrating the safety of HMBFA.