Publications by authors named "L Guzene"

Article Synopsis
  • The study investigates the variability in delineation of target volumes and organs at risk in radiation therapy, highlighting the uncertainty and lack of standardized methods in interobserver variability (IOV) studies.
  • A systematic review of 66 published IOV studies from 2018-2021 reveals issues like the independent study of organs at risk, absence of defined gold standards, and inconsistent results in key metrics like the Dice similarity coefficient.
  • To improve future IOV studies, the authors recommend standardizing methodologies and clearly defining measurements and reference standards to ensure better reproducibility and reliability of results.
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Several reports have suggested that radiotherapy after reconstructive surgery for head and neck cancer (HNC), could have deleterious effects on the flaps with respect to functional outcomes. To predict and prevent toxicities, flap delineation should be accurate and reproducible. The objective of the present study was to evaluate the interobserver variability of frequent types of flaps used in HNC, based on the recent GORTEC atlas.

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Introduction: Reconstructive surgery in head and neck cancers frequently involves the use of autologous flaps to improve functional outcomes. However, the literature suggests that postoperative radiotherapy deteriorates functional outcomes due to flap atrophy and fibrosis. Data on patterns of relapse after postoperative radiotherapy with a flap are lacking, resulting in heterogenous delineation of postoperative clinical target volumes (CTV).

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Advances in the reconstructive surgery and minimally invasive endonasal endoscopic surgery of head and neck is poorly evaluated in terms of their impact on radiotherapy planning and outcomes. These surgical advances have resulted in reduced morbidity with equivalent or better tumor control. In the absence of a recommendation on how to delineate target volumes in patients with flaps or to consider margins after endoscopic endonasal surgery, radiotherapy practices are inevitably heterogeneous.

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