Publications by authors named "L Guarente"
Article Synopsis
- Hospital-acquired infections (HAIs) pose a major global health issue, increasing patient safety risks and causing significant financial strain on healthcare systems.
- A study conducted in Rome analyzed data from over 12,000 hospital patients to assess how HAIs affected hospital costs, revealing a 53.4% increase in average costs for infected patients compared to those without infections.
- The findings underscore the necessity for targeted prevention strategies, as specific types of infections and microbes contribute to higher healthcare expenses, ultimately calling for improved efforts to minimize HAIs in hospitals.
Introduction: This study investigates the impact of invasive procedures on healthcare-associated infections (HAI) at Policlinico Universitario Tor Vergata in Rome, Italy, aiming to understand their role in device-associated HAI and to inform prevention strategies.
Methods: A retrospective cohort analysis was conducted, examining mandatory discharge records and microbiology data from 2018 across all departments. The study focused on adult patients, analysing the correlation between invasive procedures and HAI through univariate and multivariate logistic regression.
Elevated plasma total homocysteine (tHcy) is associated with the development of Alzheimer's disease and other forms of dementia. In this study, we report the relationship between tHcy and epigenetic age in older adults with mild cognitive impairment from the VITACOG study. Epigenetic age and rate of aging (ROA) were assessed using various epigenetic clocks, including those developed by Horvath and Hannum, DNAmPhenoAge, and with a focus on Index, a new principal component-based epigenetic clock that, like DNAmPhenoAge, is trained to predict an individual's "PhenoAge.
View Article and Find Full Text PDFBackground: Healthcare-associated infections (HAIs) burden healthcare globally. Amid the SARS-CoV-2 pandemic, intensified infection control measures, such as mask usage and hand hygiene, were implemented.
Aim: To assess the efficacy of these measures in preventing HAIs among hospitalized patients.