The Expression of Signaling Genes in Breast Cancer Cells.

The aim of the study was to investigate the effect of paclitaxel on the expression of genes encoding signaling factors in breast cancer cells in in vitro conditions after incubation with the said chemotherapeutic. The tested cells were harvested from the mammary glands of 36 patients with early breast cancer. The microarray technology was employed for the identification of gene expression.

Concentration of mineral requirements in bone marrow tissue of patients with lymphoma malignum.

The concentration of microelements was tested in the bone marrow tissue of 20 patients with lymphoma malignum. The patients were not treated. There was no neoplastic infiltration in their bone marrows.

Metallothione in levels in cell fractions from breast cancer tissues.

Metallothioneins (MTs) protect the cell against reactive forms of oxygen, ionizing radiation, pharmacological agents and mutagens. Metallothioneins are also responsible for neoplastic cell resistance to cytostatic drugs. The aim of this study was to determine the MT level in cell fractions as well as to determine whether there is any change in the concentration of these proteins in a neoplastic cell, and in which cell fractions this change takes place.

[Activity of isocitrate dehydrogenase in breast cancer].

The activity of isocitrate dehydrogenase (ICDH) was studied in the tissue of breast cancer and in the blood serum of the women suffering from this neoplasm. The comparative material was the physiological tissue of mammae and blood serum of the healthy women. The activity of ICDH in neoplasm tissue was more higher than in physiological tissue.

[Angiofollicular lymph node hyperplasia (Castelman's disease) in an adult woman].

Angiofollicular lymph node hyperplasia Castleman's disease) is a rare disorder of unclear etiology and wide spectrum of systemic symptoms. This report describes a case of this disorder of hyalinovascular type in 45-years old woman. The lesions were localized in axillary lymph nodes.