Publications by authors named "L Groussin"
At present, primary hyperparathyroidism is most often discovered in an asymptomatic patient, but can sometimes be revealed by a renal or bone complications. In all cases, a full work-up is recommended, with assessment of renal function (glomerular filtration rate), 24-hour calciuria, screening for risk factors for lithiasis, and renal and urinary tract imaging (ultrasound or CT scan) to look for stones or nephrocalcinosis. Bone densitometry, with measurements of the spine, femur and radius, is the recommended reference test for demineralization.
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- The study aims to identify easily measurable biomarkers that reflect the biological effects of glucocorticoids in patients with Cushing's syndrome through whole blood transcriptome analysis.
- It analyzed transcriptomic profiles from blood samples of different patient groups, creating a prediction model that effectively distinguishes between those with overt Cushing's syndrome and other conditions.
- Findings indicate that the transcriptome can indicate glucocorticoid levels, with FKBP5 expression showing potential as a nonhormonal marker for diagnosing Cushing's syndrome.