Publications by authors named "L Groppa"
Metabolic disorders are a public health issue because of the complications they cause, but they are also a major risk factor for the onset of gout.
View Article and Find Full Text PDFObjective: A3 adenosine receptor (A3AR) is overexpressed in the skin and peripheral blood mononuclear cells of psoriasis patients. We investigated the efficacy/safety of piclidenoson (CF101), an orally bioavailable A3AR agonist that inhibits IL-17 and IL-23 production in keratinocytes, in moderate-to-severe plaque psoriasis.
Methods: The randomized, placebo- and active-controlled, double-blind phase 3 COMFORT-1 trial randomized patients (3:3:3:2) to piclidenoson 2 mg BID, piclidenoson 3 mg BID, apremilast 30 mg BID or placebo.
Introduction: The costs of treating an elderly patient with gout are largely related to the treatment of concomitant pathological conditions and complications. Determining the costs of treating the disease is made by clinical and economic analysis, the task of which is to calculate the "cost of the illness".
Material And Methods: A descriptive, selective study of 237 patients with gout.
Article Synopsis
- A survey in Moldova identified the incidence of hip, proximal humerus, and distal forearm fractures, estimating 11,271 fractures in 2015 with projections of 15,863 by 2050.
- The study aimed to understand the epidemiology of osteoporotic fractures in Moldova to create a specific FRAX prediction tool for fracture risk assessment.
- The results showed that hip fracture incidence can predict other fractures and that Moldova's FRAX probabilities are higher compared to neighboring countries like Ukraine and Romania.
Purpose: To study the clinical aspects of influenza and acute respiratory viral infection (ARVI) in routine clinical practice, with efficacy and safety of the antiviral therapy evaluation.
Subjects And Methods: In the large multicenter prospective observational study were enrolled 18,946 patients aged 18 to 93 years with previously determined diagnosis of influenza or ARVI from 262 outpatient sites in Russia, Armenia, Moldova and Georgia. According to study design, 3 visits were evaluated.