Effects of vitamin B supply on cellular processes of the facultative vitamin B consumer .

Vitamin B (cobalamin, herein B) is a key cofactor for most organisms being involved in essential metabolic processes. In microbial communities, B is often scarce, largely because only few prokaryotes can synthesize B and are thus considered B-prototrophs. B-auxotrophy is mostly manifested by the absence of the B-independent methionine synthase, MetE.

The overlooked role of a biotin precursor for marine bacteria - desthiobiotin as an escape route for biotin auxotrophy.

Biotin (vitamin B) is involved in a wide range of essential biochemical reactions and a crucial micronutrient that is vital for many pro- and eukaryotic organisms. The few biotin measurements in the world's oceans show that availability is subject to strong fluctuations. Numerous marine microorganisms exhibit biotin auxotrophy and therefore rely on supply by other organisms.

Mild hypercholesterolemia and premature heart disease: do the national criteria underestimate disease risk?

Objectives: To determine the frequency of hospital admissions for acute coronary syndrome in young adults and to examine the risk factors that predispose to the development of premature heart disease.

Background: Significant coronary heart disease (CHD) is considered rare in the young adult. Current guidelines do not recommend treatment of mild cholesterol abnormalities for primary prevention of CHD in the young.