Publications by authors named "L Grimm"
Transitional cell carcinoma (TCC) of the urinary tract appears more commonly among the transplant population. The increased incidence of TCC has been primarily associated with the male gender, BK virus (BKV), and smoking. We report a case series and comprehensive review of the literature.
View Article and Find Full Text PDFImportance: Active monitoring for low-risk ductal carcinoma in situ (DCIS) of the breast has been proposed as an alternative to guideline-concordant care, but the safety of this approach is unknown.
Objective: To compare rates of invasive cancer in patients with low-risk DCIS receiving active monitoring vs guideline-concordant care.
Design, Setting, And Participants: Prospective, randomized noninferiority trial enrolling 995 women aged 40 years or older with a new diagnosis of hormone receptor-positive grade 1 or grade 2 DCIS without invasive cancer at 100 US Alliance Cancer Cooperative Group clinical trial sites from 2017 to 2023.
Article Synopsis
- The age of newly diagnosed breast tumors provides important insights into their causes and potential outcomes, as it reflects the time from when the tumor starts growing until it is detected.
- Researchers estimate this age using a novel method based on epigenetic changes rather than traditional age-related markers, revealing that younger tumors tend to be more aggressive with higher growth rates and instability.
- These findings highlight the potential of this epigenetic approach for better risk assessment and early detection of breast cancer by distinguishing between aggressive young tumors and older, more stable ones.
Article Synopsis
- The success of image-guided breast biopsies is not just about technical skills but also heavily relies on a positive patient experience.
- Factors affecting patient experience include the procedure's environment, effective communication with healthcare providers, and managing patients' expectations and potential complications.
- The review discusses literature and survey results that highlight strategies to address common biopsy complications and enhance the overall patient experience during the process.