Publications by authors named "L Greenberg"
An integrated, multidisciplinary management team intervention to improve patient-centeredness, HIV, and maternal-child outcomes in Lesotho: formative research on participatory implementation strategies.
BMC Health Serv Res
December 2024
Background: Reducing perinatal HIV transmission and optimizing maternal and child health (MCH) outcomes in high HIV prevalence settings is an urgent, but complex, priority. Extant interventions over-emphasize individual-level provider and patient behaviors, and neglect critical health systems-level changes. The 'Integrated Management Team to Improve Maternal-Child Outcomes (IMPROVE)' study implemented a three-part, patient-centered, health-systems-level intervention to improve MCH and HIV outcomes in Lesotho.
View Article and Find Full Text PDFSecretory cargos are exported from the ER via COPII coated vesicles that have an inner matrix of Sec23/Sec24 heterotetramers and an outer cage of Sec13/Sec31 heterotetramers. In addition to COPII, Sec13 is part of the nuclear pore complex (NPC) and the regulatory SEA/GATOR complex in eukaryotes, which typically have one Sec13 orthologue. The kinetoplastid parasite has two paralogues: TbSec13.
View Article and Find Full Text PDFSkeletal muscle actin (ACTA1) mutations are a prevalent cause of skeletal myopathies consistent with ACTA1's high expression in skeletal muscle. Rare de novo mutations in ACTA1 associated with combined cardiac and skeletal myopathies have been reported, but ACTA1 represents only ~20% of the total actin pool in cardiomyocytes, making its role in cardiomyopathy controversial. Here we demonstrate how a mutation in an actin isoform expressed at low levels in cardiomyocytes can cause cardiomyopathy by focusing on a unique ACTA1 variant, R256H.
View Article and Find Full Text PDFArticle Synopsis
- - Acute lower respiratory tract infection (ALRI) is a leading cause of child mortality globally, particularly affecting children in Papua New Guinea (PNG) due to Streptococcus pneumoniae.
- - Researchers conducted whole-exome sequencing on children in PNG and found a specific genetic variant (a single-nucleotide variant in the COQ6 gene) that is linked to higher morbidity from ALRI, with evidence from both human and mouse studies supporting its role.
- - The COQ6 variant plays a significant role in the biosynthesis of ubiquinone and impacts how the immune system responds to infections, highlighting a new genetic risk factor for pneumonia in PNG and the enzyme's involvement in inflammatory responses.
Purpose: We examined the association between iron deficiency anemia (IDA) and severe maternal morbidity (SMM) during delivery and up to 1-year postpartum.
Methods: In a retrospective cohort study across 3 states, we computed adjusted relative risks (aRR) for SMM comparing individuals with IDA versus those without, using modified Poisson regression models.
Results: Among 2459,106 individuals, 10.