Publications by authors named "L Goumidi"
Venous thromboembolism (VT) is a frequent (annual incidence of 1 to 2 per 1,000) and potentially life-threatening (case-fatality rate up to 10%) disease. VT is associated with serious short-term and long-term complications including a recurrence rate of approximately 20% within five years. Anticoagulant therapy, the mainstay of VT treatment, drastically reduces the risk of early VT recurrence, but it exposes patients to a substantial risk of bleeding.
View Article and Find Full Text PDFHigh risk of long-term recurrence after a first episode of venous thromboembolism during pregnancy or postpartum: the REcurrence after a PrEgnAncy related Thrombosis (REPEAT) Study.
J Thromb Haemost
October 2024
Background: The long-term recurrence risk after a pregnancy-associated venous thromboembolism (VTE) is sparsely assessed.
Objectives: To determine the rate of recurrence after a pregnancy-associated VTE and identify associated risk factors.
Methods: Five hundred eighty-seven women with a history of first VTE occurring during pregnancy or up to 3 months after delivery were referred to La Timone Hospital, Marseille, France.
Article Synopsis
- The thrombin generation assay (TGA) measures how well plasma can produce thrombin, which helps assess an individual's blood clotting ability.
- The study sought to find new biological factors affecting thrombin generation by analyzing data from 770 venous thrombosis patients and validating findings in 536 healthy individuals.
- Results showed that complement proteins C5 and C9 were significantly linked to thrombin generation, with C9 having a notable impact when tested in the lab, suggesting these proteins could influence clotting, though more research is needed to clarify their roles.
Background: Light transmission aggregation (LTA) is used widely by the clinical and research communities. Although it is a gold standard, there is a lack of interlaboratory harmonization.
Objectives: The primary objective was to assess whether sources of activators (mainly adenosine diphosphate [ADP], collagen, arachidonic acid, epinephrine, and thrombin receptor activating peptide6) and ristocetin contribute to poor LTA reproducibility.