Publications by authors named "L Gopcsa"
We report the case of long-term persisting rheumatoid arthritis (RA), treated with CD20-CD19 CAR-T when it became associated with diffuse large B cell lymphoma (DLBCL), resulting in a sustained drug-free remission of the preceding RA, as well as of the subsequent DLBCL that formed the indication of the CAR-T therapy using zamtocabtagene autoleucel, with a 1-year follow-up. According to our best knowledge, this is the first published clinical case report of long-term persisting RA treated with CAR-T cell therapy.
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- Thromboinflammation and immunothrombosis influence diseases like TTP and COVID-19, but TTP's cytokine profiles are not well-studied compared to COVID-19's cytokine storms.
- A study measured 33 soluble mediators in patients with TTP and COVID-19 to identify unique and shared features of thromboinflammation.
- The findings revealed that TTP has a more anti-inflammatory profile during acute phases with fewer immune markers, while COVID-19 shows increased pro-inflammatory markers with severity, suggesting distinct mechanisms between the two diseases.
Article Synopsis
- Acquired Hemophilia A (AHA) is an unusual autoimmune disorder that can cause severe bleeding due to inhibitors targeting Factor VIII, often emerging after certain treatments.
- The study involved a 68-year-old man who developed AHA after taking adalimumab for rheumatoid arthritis, leading to significant bleeding that required specialized treatment with recombinant Factor VIIa.
- This case highlights the need for quick coagulation assessments in rheumatoid arthritis patients on adalimumab and reviews existing literature on drug-induced AHA, aiming to improve awareness and prompt intervention among healthcare professionals.
Background: Monoclonal gammopathy (MG) is characterized by monoclonal protein overproduction, potentially leading to the development of hyperviscosity syndrome.
Objective: To assess retinal circulation using optical coherence tomography angiography (OCTA) parameters in patients with monoclonal gammopathy.
Methods: OCTA measurements were performed using the Optovue AngioVue system by examining 44 eyes of 27 patients with MG and 62 eyes of 36 control subjects.