Publications by authors named "L Goldberger"
Article Synopsis
- Aberrant angiogenesis may contribute to cognitive decline and could serve as a therapeutic target for dementia prevention, though most prior studies have focused on animal models.
- This study evaluated the relationship between blood markers of angiogenesis and cognitive aging in a sample of 435 older adults, revealing significant associations that varied by sex, particularly in younger women compared to men.
- Results indicated that higher levels of certain angiogenic markers were linked to better executive function and less brain atrophy, suggesting the potential for targeting angiogenesis in addressing age-related cognitive impairment.
Aberrant angiogenesis could contribute to cognitive impairment, representing a therapeutic target for preventing dementia. However, most angiogenesis studies focus on model organisms. To test the relevance of angiogenesis to human cognitive aging, we evaluated associations of circulating blood markers of angiogenesis with brain aging trajectories in two deeply phenotyped human cohorts (n=435, age 74 + 9) with longitudinal cognitive assessments, biospecimens, structural brain imaging, and clinical data.
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- The study reveals high levels of hydrochloric acid (HCl) and halogens (Cl, Br, and BrCl) in an industrial plume near the Great Salt Lake, Utah, highlighting a significant environmental concern.
- Complete oxygen depletion was linked to the production of halogen radicals, correlating with reported emissions from nearby facilities for chlorine and HCl, but bromine levels were estimated based on unreported inventory data.
- A photochemical model demonstrated that bromine radicals were the primary cause of rapid oxygen depletion, and including halogen emissions in environmental models indicated a 10%-25% increase in particulate matter in the Great Salt Lake Basin, exacerbating air quality problems in the region.
Physical activity (PA) is associated with preserved age-related body and brain health. However, PA quantification can vary. Commercial-grade wearable monitors are objective, low burden tools to capture PA but are less well validated in older adults.
View Article and Find Full Text PDFBlood-based inflammatory markers hold considerable promise for diagnosis and prognostication of age-related neurodegenerative disease, though a paucity of research has empirically tested how reliably they can be measured across different experimental runs ("batches"). We quantified the interbatch reliability of 13 cytokines and chemokines in a cross-sectional study of 92 community-dwelling older adults (mean age = 74; 48% female). Plasma aliquots from the same blood draw were parallelly processed in 2 separate batches using the same analytic platform and procedures (high-performance electrochemiluminescence by Meso Scale Discovery).
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