Publications by authors named "L Glennie"
Article Synopsis
- Palmoplantar keratoderma (PPK) is a skin condition that causes thick skin and abrasions on the hands and feet, linked to genetic factors, including mutations in a specific gene.
- A new harmful variant (c.794G>C, p.Arg265Pro) in this gene was found in a 60-year-old female PPK patient, who had various symptoms such as skin changes, brittle nails, and thin hair.
- This study suggests that the identified gene variant affects the stability of a protein crucial for WNT signaling, which is important for skin health, indicating that disrupted signaling may contribute to the development of PPK in the patient.
This review summarizes the recent Global Meningococcal Initiative (GMI) regional meeting, which explored meningococcal disease in North America. Invasive meningococcal disease (IMD) cases are documented through both passive and active surveillance networks. IMD appears to be decreasing in many areas, such as the Dominican Republic (2016: 18 cases; 2021: 2 cases) and Panama (2008: 1 case/100,000; 2021: <0.
View Article and Find Full Text PDFProteolysis-targeting chimeras (PROTACs) bring a protein of interest (POI) into spatial proximity of an E3 ubiquitin ligase, promoting POI ubiquitylation and proteasomal degradation. PROTACs rely on endogenous cellular machinery to mediate POI degradation, therefore the subcellular location of the POI and access to the E3 ligase being recruited potentially impacts PROTAC efficacy. To interrogate whether the subcellular context of the POI influences PROTAC-mediated degradation, we expressed either Halo or FKBP12 (dTAG) constructs consisting of varying localization signals and tested the efficacy of their degradation by von Hippel-Lindau (VHL)- or cereblon (CRBN)-recruiting PROTACs targeting either Halo or dTAG.
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