The regulatory network that controls lymphopoiesis.

Lymphopoiesis is the generation of the T, B and NK cell lineages from a common lymphoid-biased haematopoietic stem cell. The experimental study of this process has generated a large amount of cellular and molecular data. As a result, there is a considerable number of mathematical and computational models regarding different aspects of lymphopoiesis.

High prevalence of alcohol use disorders in 454 young adult offspring from the San Diego prospective study.

Background: Preliminary evaluations of 212 drinking offspring from the San Diego Prospective Study (SDPD) indicated that over 50% developed alcohol use disorder (AUD) by their mid-20s. The present analysis evaluated if those findings remained robust when the group increased to 454 individuals, a sample size that facilitated a search for potential contributors to the high AUD prevalence.

Methods: Semistructured interviews were used to evaluate lifetime AUD diagnoses in 224 daughters and 230 sons from the SDPS (N = 454) by mean age 26.

Recognition of static and dynamic emotional facial expressions in mild cognitive impairment, healthy elderly and young people.

Introduction: The ability to recognize emotions is essential for social cognition, and its impairment can affect social interactions, contributing to loneliness and the worsening of issues in individuals with mild cognitive impairment (MCI). This study aims to investigate the ability to recognize emotional facial expressions in MCI individuals compared to healthy elderly and young individuals.

Method: We evaluated 27 MCI individuals, 31 healthy elderly, and 29 healthy young participants using two tasks: one with static facial expressions (photographs) and another with dynamic ones (video clips).

Geographical distribution of human pythiosis in the USA.

For more than 100 years, the infections caused by have been well documented in horses. However, recently, pythiosis was also described in several species, including dogs, cats, cattle, zoo captive animals, and humans. Human pythiosis is a life-threatening infection requiring an early diagnosis for a successful management.

Cognitive outcomes after magnetic resonance-guided laser interstitial thermal therapy for mesial temporal lobe epilepsy in adolescent patients.

Surgical treatment of medication-resistant mesial temporal lobe epilepsy (MTLE) is associated with cognitive deficits. Magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) for MTLE has been shown to result in superior cognitive outcomes in adults when compared to open surgical resection. However, data regarding postoperative cognitive outcomes in adolescent and pediatric patients is limited.