Cerebrospinal fluid biomarkers as predictors of multiple sclerosis severity.

Background: Prognostic biomarkers at multiple sclerosis (MS) onset to predict disease severity may help guide initial therapy selection for people with MS. Over 20 disease-modifying treatments (DMTs) of varying levels of risk and efficacy now exist. The ability to predict MS severity would help to identify those patients at higher risk where a highly effective, but potentially risky, therapy would be optimal.

Open-label, controlled, phase 2 clinical trial assessing the safety, efficacy, and pharmacokinetics of INM004 in pediatric patients with Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome.

Background: Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome (STEC-HUS) is a severe condition mainly affecting children. It is one of the leading causes of acute kidney injury in the pediatric population. There is no established therapy for this disease.

Magnetic Sensor Array for Electric Arc Reconstruction in Circuit Breakers.

Noninvasive imaging of circuit breakers under short-circuit testing is addressed by recording the magnetic field produced over an array of external sensors and by solving an inverse problem to identify the causing current distribution. The temporal and spatial resolution of the sensing chain are studied and implemented in a physical set-up. A wire model is adopted to describe electrical current distribution.

Water quality and dissolved load in the Chirchik and Akhangaran river basins (Uzbekistan, Central Asia).

Uzbekistan (Central Asia) is experiencing serious water stress as a consequence of altered climate regime, past over-exploitation, and dependence from neighboring countries for water supply. The Chirchik-Akhangaran drainage basin, in the Tashkent province of Uzbekistan, includes watersheds from the Middle Tien Shan Mountains escarpments and the downstream floodplain of the Chirchik and Akhangaran rivers, major tributaries of the Syrdarya river. Water in the Chirchik-Akhangaran basin is facing potential anthropogenic pressure from different sources at the scale of river reaches, from both industrial and agricultural activities.

A "glympse" into neurodegeneration: Diffusion MRI and cerebrospinal fluid aquaporin-4 for the assessment of glymphatic system in Alzheimer's disease and other dementias.

The glymphatic system (GS) is a whole-brain perivascular network, consisting of three compartments: the periarterial and perivenous spaces and the interposed brain parenchyma. GS dysfunction has been implicated in neurodegenerative diseases, particularly Alzheimer's disease (AD). So far, comprehensive research on GS in humans has been limited by the absence of easily accessible biomarkers.