Publications by authors named "L Gheddar"

Trazodone, a medicine registered for human, is a serotonin agonist-antagonist. At low dose, the drug is sedative due to its antagonist properties. At high dose, it is an agonist with anxiolytic and antidepressant actions.

View Article and Find Full Text PDF

The presence of a doping substance in an athlete's biological sample may not be only related to intentional pharmacological support. The unintended use of a prohibited substance may be due various reasons. This paper describes the case of a Polish canoeist preparing for the 2024 Summer Olympics in Paris who presented a positive doping test result, as a consequence of administering medication to her injured dog.

View Article and Find Full Text PDF

A case of chronic intoxication by 2,4-dinitrophenol (2,4-DNP) is reported in a 21-year-old bodybuilder, also known as an abuser of anabolic steroids, who died after ingesting 2 grams of this substance after 6 months of repeated consumption. The bodybuilder presented the triad of symptoms - tachycardia, tachypnoea, profuse sweating - from 6 months before his death, and was hospitalised for multiple organ failure 4 months before his death. Medical staff attributed this serious episode to his consumption of 2,4-DNP.

View Article and Find Full Text PDF
Article Synopsis
  • - Clomiphene, a selective estrogen receptor modulator (SERM) used to boost female fertility, is banned in sports as it can affect testosterone levels, thus appearing on the World Anti-Doping Agency's list of prohibited substances.
  • - A male athlete tested positive for clomiphene with low urine concentrations and challenged the ruling; a subsequent hair test confirmed repeated exposure over six months.
  • - Investigation revealed that egg powder (albumin), which the athlete consumed regularly, contained significant levels of clomiphene, contributing to the positive drug test due to its long elimination half-life.
View Article and Find Full Text PDF

Clostebol, the 4-chloro derivative of testosterone, available as Over The Counter product in pharmacies and drugstores in several countries, is mostly commercialized as a cream or spray in the form of acetate ester. As other anabolic steroids, clostebol is listed as a prohibited substance by the World Anti-Doping Agency (WADA). Controlled transdermal application of clostebol acetate has been reported to produce detectable amounts of its metabolites in urine, even after a single exposure.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionneknpp46l09b89hjjiukblni7mfjdgaq): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once