Publications by authors named "L Garmendia"
Background: Controlling uterine contractile activity is essential to regulate the duration of pregnancy. During most of the pregnancy, the uterus does not contract (i.e.
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- The study investigates how stress impacts tumor development in female OF1 mice, particularly focusing on the link between stress, cancer progression, and mental health, which has been less studied in females compared to males.
- The research employed the Chronic Social Instability Stress (CSIS) model, revealing that female mice under stress showed weight loss and increased arousal but no signs of depression or anxiety, and stress did not affect tumor growth or corticosterone levels but did alter inflammatory markers in the brain.
- The findings highlight significant sex differences in the biological response to stress and suggest the importance of considering these differences in future cancer research, as female mice seem to respond to stress differently than male mice.
Women are twice as likely as men to develop depression and antidepressant treatment is more frequent in females. Moreover, neuroinflammatory changes related to affective disorders differ in accordance with sex. Despite this evidence, female populations have been largely omitted from preclinical experiments studying antidepressants.
View Article and Find Full Text PDFThe aims of this study were to identify behavioral strategies to cope with social defeat, evaluate their impact on tumor development and analyze the contributions of both to changes in physiology and behavior produced by chronic defeat stress. For this purpose, OF1 mice were inoculated with B16F10 melanoma cells and subjected to 18 days of repeated defeat stress in the presence of a resident selected for consistent levels of aggression. Combined cluster and discriminant analyses of behavior that manifested during the first social interaction identified three types of behavioral profiles: active/aggressive (AA), passive/reactive (PR) and an intermediate active/non-aggressive (ANA) profile.
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- - The study investigates how different coping strategies impact psychological distress, cortisol, and TNF-a levels in breast cancer survivors post-treatment.
- - A total of 54 survivors participated, completing questionnaires on coping and anxiety/depression, along with providing blood samples for analysis.
- - Results showed that those using passive coping strategies experienced higher levels of psychological distress and biological markers (cortisol and TNF-a), indicating they relied more on avoidance and negative self-talk rather than constructive problem-solving.