Multidisciplinary interventions in ectodermal dysplasia: A clinical case report.

Ectodermal dysplasia (ED) is a spectrum of inherited disorders that compromise the development and function of ectodermal structures, like hair, nails, and teeth. This case report describes a 17-year-old male with sparse hair and cognitive difficulties who was diagnosed with ED in childhood. A multidisciplinary evaluation with dermatology, neurology, and dentistry revealed characteristic clinical features, and the histopathological diagnosis was confirmed via punch biopsy.

Injectable hydrogels for treating skin injuries in diabetic animal models: a systematic review.

Purpose: One of the main causes of chronic wounds is diabetes mellitus (DM), a metabolic disease characterized by chronic hyperglycemia. In this context, hydrogels have been used as a promising treatment for stimulating tissue ingrowth and healing in these injuries. This systematic review aimed to evaluate the findings of studies that investigated the effects of injectable hydrogels of various origins on skin wound healing using in vivo experimental models in diabetic rats.

Bacterial purine metabolism modulates C. elegans development and stress tolerance via DAF-16.

The purine metabolism is crucial for cellular function and is a conserved metabolic network from prokaryotes to humans. While extensively studied in microorganisms like yeast and bacteria, the impact of perturbing dietary intermediates from the purine biosynthesis on animal development and growth remains poorly understood. We utilized Caenorhabditis elegans as the metazoan model to investigate the mechanisms underlying this deficiency.

Internet gaming disorder and the alternative five factor personality model: a study in a Spanish community sample.

Background: This study was designed to examine the prevalence and relationships between the Internet gaming disorder (IGD) behaviors, suggested by the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), and personality traits.

Participants And Procedure: A sample community of 1,548 subjects, 707 men and 841 women, with a mean age of 40.90 and 38.

Pharmacodynamics of the orexin type 1 (OX) receptor in colon cancer cell models: A two-sided nature of antagonistic ligands resulting from partial dissociation of Gq.

Background And Purpose: Orexins have important biological effects on the central and peripheral nervous systems. Their primary ability is to regulate the sleep-wake cycle. Orexins and their antagonists, via OX receptor have been shown to have proapoptotic and antitumor effects on various digestive cancers cell models.