Publications by authors named "L Galati"
HPV16 is responsible for approximately 60% and 90% of global HPV-induced cervical and oropharyngeal cancers, respectively. HPV16 intratype variants have been identified by HPV genome sequencing and classified into four phylogenetic lineages (A-D). Our understanding of HPV16 variants mostly derives from epidemiological studies on cervical cancer (CC) in which HPV16 B, C, and D lineages (previously named "non-European" variants) were mainly associated with high-grade cervical lesions and cancer.
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- - Merkel Cell Carcinoma (MCC) is a rare skin cancer influenced by the MCPyV virus, which affects specific genes, particularly NDRG1, crucial for controlling cell growth and movement.
- - The study identified the SET protein, which regulates NDRG1, and found that its expression is heightened in both MCC cells and tumor tissues.
- - Using the inhibitor FTY720 to block the interaction between SET and PP2A led to increased NDRG1 levels and reduced cell proliferation, suggesting that targeting SET could be a potential treatment strategy for MCC.
Sjögren's disease is an autoimmune disorder affecting exocrine glands, causing dry eyes and mouth and other morbidities. Polypharmacy or a history of radiation to the head and neck can also lead to dry mouth. Sjogren's disease is often underdiagnosed due to its non-specific symptoms, limited awareness among healthcare professionals, and the complexity of diagnostic criteria, limiting the ability to provide therapy early.
View Article and Find Full Text PDFIncidence of conjunctival squamous cell carcinoma (cSCC) in Zimbabwe is >30-fold higher than the global average. cSCC risk is notably higher among people with human immunodeficiency virus, implicating impaired immune response and a yet unknown infectious etiology. Formalin-fixed, paraffin-embedded blocks from Zimbabwe, comprising conjunctival precancer (n = 78), invasive cSCC cases (n = 148) and nonmalignant eye lesions (n = 119), were tested for multiple DNA viruses using Luminex bead-based technology.
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- Around 12% of cancers worldwide are linked to infectious agents, mostly classified as Group 1 carcinogens by the IARC, particularly various viruses.
- Key oncogenic viruses include hepatitis B and C, Epstein-Barr virus, and high-risk human papillomaviruses (HPVs), with some polyomaviruses also suspected of causing cancer in immunocompromised individuals.
- The connection between these viruses and cancer has led to effective prevention strategies, such as vaccinations against HPV and HBV, significantly reducing cancer cases associated with these viruses.