Publications by authors named "L Galanti"
Background: Closed system transfer devices (CSTD) help to reduce the exposure of healthcare professionals to hazardous drugs. They may be used in stability studies conducted on anticancer drugs. During a stability study about polyolefin bags of gemcitabine, Tevadaptor® device was suspected of causing a bias in the evaluation of the concentrations of the first aliquots extracted from the bags.
View Article and Find Full Text PDFObjective: Esketamine (Vesierra) is a molecule, used alone or in combination, to induce and maintain general anaesthesia and to relieve pain in emergency medicine. The aim of this study is to evaluate the long-term physicochemical stability of a 1 mg/mL solution of esketamine diluted in 0.9% sodium chloride (NaCl) and stored in polypropylene syringes at 5±3°C during 65 days (64+1 day at 22±3°C) and 72 hours at 22±3°C (room temperature), in order to centralise preparation under aseptic conditions in hospital pharmacy.
View Article and Find Full Text PDFArticle Synopsis
- DNA double-strand breaks (DSBs) can be repaired through various pathways, with the choice of pathway influenced by the cell cycle and the activation of cyclin-dependent kinases (CDKs).
- Research identifies Dbf4-dependent kinase (DDK) as a crucial second regulator for DNA end resection, working alongside CDKs to facilitate homologous recombination (HR).
- DDK activates resection nucleases like Sae2 and Dna2 in budding yeast, and its synthetic activation allows limited DSB repair even in G1 phase cells, highlighting its importance in the repair process.
Context: Exocyclic DNA adducts have been shown to be potential biomarkers of cancer risk related to oxidative stress and exposure to aldehydes in smokers. In fact, aldehydes potentially arise from tobacco combustion directly and endogenously through lipid peroxidation.
Objective: This study aims to investigate the relationship between a profile of nine aldehydes-induced DNA adducts and antioxidant activities, in order to evaluate new biomarkers of systemic exposure to aldehydes.