The place of beta-adrenergic receptor blockers in the treatment of arterial hypertension: From bench-to-bedside.

Arterial hypertension is a multifaceted condition influenced by numerous pathophysiological factors. The key contributors to its pathogenesis encompass an unhealthy lifestyle, dysregulation of the sympathetic nervous system, alterations in the activity of adrenergic receptors, disruptions in sodium metabolism, structural and functional abnormalities in the vascular bed, as well as endothelial dysfunction, low-grade inflammation, oxidative stress etc. Despite extensive research into the mechanisms of arterial hypertension development over the centuries, its pathogenesis remains incompletely understood, and the selection of an effective treatment strategy continues to pose a significant challenge.

THE BONE-BRAIN AXIS? BIOPSYCHOSOCIAL ASPECTS OF ORTHOPEDICS AND A MENTAL WELLBEING ACTION PLAN IN MUSCULOSKELETAL CARE.

Objective: The aim: To review the biopsychosocial aspects of psychiatric comorbidity in patients with musculoskeletal conditions and recommend a relevant mental health action plan.

Patients And Methods: Materials and methods: Keywords (orthopedics, psychiatry, mental health) were used to list down and analyze the literature in PubMed and Google Scholar. All types of articles, including original research, systematic reviews, and meta-analyses, along with gray literature dating back to 2000.

Urotensin-II As a Promising Key-Point of Cardiovascular Disturbances Sequel.

Arterial hypertension is a highly urgent problem of modern medicine since the crisis of blood pressure control remains open, due to the increasing number of uncontrolled arterial hypertension. Today, one of the most critical problems of cardiology is the study of the mechanisms of development and progression of arterial hypertension. Therefore, our international and multidisciplinary working group presents a vision of a new therapeutic target - urotensin II in the pathogenesis of arterial hypertension.

PHARMACEUTICAL ACTIVATORS OF ATP-DEPENDENT POTASSIUM CHANNELS AS POTENTIAL NEPHROPROTECTORS AGAINST GLOMERULAR AND TUBULAR DAMAGE TO THE NEPHRON (REVIEW).

Considering the incidence, high risk of progression and severe consequences of renal pathology, a preventive therapy as well as correction of kidney dysfunction are issues of a great importance today. An essential condition for an improvement of nephroprotection is a determination of new mechanisms of disturbances and restoration of homeostatic kidney processes. A unique physiological role of ATP-dependent potassium (KATP) channels and their participation in adaptive-compensatory reactions substantiate the feasibility of search for effective nephroprotectors among pharmacological modulators of their activity.

NICORANDIL EFFICACY IN THE TREATMENT OF ISCHEMIC HEART DISEASE (REVIEW).

Nicorandil is an antianginal agent with a dual mechanism of action. It belongs to ATP-senitive potassium channel openers which has the beneficial effect in angina pectoris, playing an significant role in the dilation of arteries, veins and coronary artery. It leads to the relaxation of vascular smooth muscle and causes vasodilatation of major epicardial vessels.