Publications by authors named "L GARRETA"

Article Synopsis
  • Genome-wide association studies (GWASs) help identify the genetic factors behind phenotypic variations in various organisms, but current methods struggle with replication and tetraploid data.
  • The MultiGWAS tool was developed to conduct GWAS for both diploid and tetraploid organisms, integrating four software packages to enhance analysis capabilities.
  • Testing with public tetraploid potato data shows MultiGWAS outperforms individual software in detecting reliable genetic associations, making it a valuable option for researching polyploid organisms.
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Background: Several studies have shown that genomes can be studied via a multifractal formalism. Recently, we used a multifractal approach to study the genetic information content of the Caenorhabditis elegans genome. Here we investigate the possibility that the human genome shows a similar behavior to that observed in the nematode.

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The Caenorhabditis elegans genome has several regular and irregular characteristics in its nucleotide composition; these are observed within and between chromosomes. To study these particularities, we carried out a multifractal analysis, which requires a large number of exponents to characterize scaling properties. We looked for a relationship between the genetic information content of the chromosomes and multifractal parameters and found less multifractality compared to the human genome.

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This multicenter retrospective study included 56 cases of histologically reviewed invasive epithelial thymic tumors. All these patients underwent surgical treatment or exploration and were referred for complementary radiotherapy. The majority received a dose higher than 4000 rad.

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