Publications by authors named "L G Zakharova"

Unlabelled: Glial cell line-derived neurotrophic factor (GDNF) is essential in maintaining the viability, function and differentiation of neuronal cells. In addition to its function in healthy nervous tissue, GDNF is involved in pathological processes, such as glioma growth. GDNF is represented by 2 main isoforms: pre-α-pro-GDNF (αGDNF) and pre-β-pro-GDNF (βGDNF).

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Recently, supramolecular self-assembly has attracted the attention of researchers worldwide because it enables the creation of nanostructures with unique properties without additional costs. Spontaneous organization of molecules allows the design and development of new nanostructures that can interact with drugs and living cells and generate a response. Therefore, supramolecular structures have enormous potential and can be in demand in various fields of healthcare and ecology.

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The low solubility of α-tocopherol in water and its susceptibility to photodegradation make it difficult for biological systems to absorb this natural antioxidant. To overcome these limitations, α-tocopherol was encapsulated in low-toxicity nanocontainers, namely, niosomes based on Tween 80 and cholesterol. The niosomes were modified with cationic surfactants containing a carbamate fragment.

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Article Synopsis
  • A supramolecular method was used to create nanoparticles by combining sodium carboxymethylcellulose and viologen calix[4]resorcinol in water at room temperature, driven by self-assembly.
  • The properties of the nanoparticles varied based on the ratio of polymer to macrocycle, with excess macrocycle enabling binding of oleic acid and excess polymer allowing for doxorubicin binding.
  • The nanoparticles showed enhanced solubilization of quercetin and better delivery into tumor cells compared to simpler compositions, paving the way for advancements in drug delivery systems.
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