Publications by authors named "L G Wolfe"
Multiple sclerosis (MS) is initially characterized by myelin and axonal damage in central nervous system white matter lesions, but their causal role in synapse loss remains undefined. Gray matter atrophy is also present early in MS, making it unclear if synaptic alterations are driven by white matter demyelinating lesions or primary gray matter damage. Furthermore, whether axonal pathology occurs secondary to or independent of demyelination to drive synaptic changes is not clear.
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- - A rare genetic condition involving mitochondrial complex III deficiency and lactic acidosis, characterized by scalp alopecia, was identified in two unrelated cases and discussed further with a participant from the Undiagnosed Diseases Network (UDN).
- - The participant had two autosomal recessive disorders discovered through genome sequencing: mitochondrial complex III deficiency and cataracts, with specifics on previously documented pathogenic variants for each condition.
- - A combination of enzyme assays and cellular proteomics showed clear dysfunction in complex III and low levels of a crucial protein, validating the genetic mutations' pathogenic effects and broadening understanding of these rare disorders.
Article Synopsis
- Using oral swabs to collect remnants of stomach content during rumination in dairy cows can closely replicate ruminal bacterial communities, making it beneficial for large-scale studies on the rumen microbiome.
- The quality of these swabs can vary, affecting their ability to accurately reflect the microbiome due to factors such as sampling time, cow behavior, and swab color.
- Our research shows that darker swabs correlate with increased bacterial diversity while lighter swabs display greater variation; darker swabs also relate to the ruminal fungal community, indicating their potential as a more accurate representation of the ruminal environment.