The power of randomization by sex in multilocus genetic evolution.

Background: Many hypotheses have been proposed for how sexual reproduction may facilitate an increase in the population mean fitness, such as the Fisher-Muller theory, Muller's ratchet and others. According to the recently proposed mixability theory, however, sexual recombination shifts the focus of natural selection away from favoring particular genetic combinations of high fitness towards favoring alleles that perform well across different genetic combinations. Mixability theory shows that, in finite populations, because sex essentially randomizes genetic combinations, if one allele performs better than another across the existing combinations of alleles, that allele will likely also perform better overall across a vast space of untested potential genotypes.

Sex: The power of randomization.

In evolutionary biology, randomness has been perceived as a force that, in and of itself, is capable of inventing: mutation creates new genetic information at random across the genome which leads to phenotypic change, which is then subject to selection. However, in science in general and in computer science in particular, the widespread use of randomness takes a different form. Here, randomization allows for the breaking of pattern, as seen for example in its removal of biases (patterns) by random sampling or random assignment to conditions.

[Species composition of yeast-like fungi isolated from HIV-infected patients].

The strains of yeast-like fungi isolated from HIV-infected people in 1994-2005 were examined. It was found that a share of non-albicans strains increased up to 46.2%, in monoculture they were present in 40% of examined patients, Candida glabrata (21.

[Antimycotic sensitivity of yeast-like fungi isolated from HIV-infected patients].

Sensitivity of museum and fresh strains to antimycotics has been determined. 5-Fluorocytosine (86.2%) and amphotericine B (93.